DNA Profiling
Frequently asked questions about DNA profiling
- What is DNA profiling?
- What are the benefits of DNA profiling?
- What are the principles of DNA profiling?
- Are there any probable defence challenges to DNA profiling?
- Are there any efforts towards the standardisation and internationalisation
of DNA profiling world-wide?
- Is INTERPOL also involved in these activities?
- What is the INTERPOL DNA profile Monitoring Expert Group
(DNA MEG) about and what are its tasks?
| 1.
What is DNA profiling? |
|
|
DNA profiling is a process which begins when a minute sample of genetic material
- DNA (deoxyribonucleic acid) - is taken from human tissue and ends when
the sample is given a computerised numeric value in the form of a 'bar code'.
Comparing a person's DNA profile with a DNA sample retrieved from the scene
of a crime can eliminate innocent people, but can also provide a strong indication
of guilt.
| 2.
What are the benefits of DNA profiling? |
|
|
The experience acquired by countries already using DNA profiling in their crime
investigations shows that there are several important advantages to be gained:
- rapid and absolute elimination of innocent suspects;
- rapid identification of offenders with a very high degree of certainty;
- reliability of evidence produced in court;
- better administration of justice;
- increased public confidence in the criminal justice system;
- a deterrent effect on offenders with a concomitant decrease in crime;
- cost-effectiveness in terms of investigation time saved.
| 3.
What are the principles of DNA profiling? |
|
|
The principle on which DNA profiling is based is relatively straightforward:
a series of molecular biology techniques is used to determine the sizes of discrete
DNA fragments that contain hypervariable target sequences. Because molecular
biology is a new discipline with technical possibilities that are still expanding,
it is hardly surprising that a variety of 'standard' techniques are used at
each step in DNA profiling. The analysis principles, however, remain constant.
They include:
- collecting samples from the scene of a crime and from victims and suspects;
- extracting and purifying DNA from all the samples;
- cutting the DNA into fragments (with a 'restriction enzyme');
- visualising the fragments;
- analysing the resulting bank patterns by computer.
DNA profiling is a complicated process. As already mentioned, each sequential
step involved in generating a DNA profile can be carried out in a variety of
ways. Although they are all straightforward, and factors affecting them have
been documented, each step is performed differently in different laboratories.
Much of this variation is of little account, but in the present unregulated
climate there remains a very real potential for generating a variety of anomalies.
| 4.
Are there any probable defence challenges to DNA profiling? |
|
|
Yes, the investigating officers and prosecutors using DNA profiling should
be aware of several areas where the defence could challenge evidence successfully.
The main points that could be raised are:
- possible contamination of samples which could lead to a different interpretation
of results or their invalidation;
- comparison with an inadequate population sample size as the basis for the
probability calculations;
- improper sample handling or the unreliability of laboratory procedures.
| 5.
Are there any efforts towards the standardisation and internationalisation
of DNA profiling world-wide? |
|
|
Yes, it is essential that standards be established and rules on accreditation
and auditing applied at both national and international levels. Only if there
is one will there be a possibility to exchange data internationally.
Europe seems to be a very active region from this point of view. The European
DNA Profiling Group (EDNAP) was set up in 1988 and it has made considerable
progress. The aim of this informal group is to facilitate the exchange of compatible
DNA profiling data in order to allow European countries to make the best possible
use of the opportunities provided by this technique. The European co-operation
in this topic was reinforced and formalised by the involvement of the European
Union (EU). Within this framework, there is a Working group on Police Co-operation,
which deals also with DNA related topics. The society of forensic scientists
is represented by the European Network of Forensic Science Institutes (ENFSI)
Working Group on DNA Profiling.
| 6.
Is INTERPOL also involved in these activities? |
|
|
Yes, of course. The 25th Regional Conference (Warsaw, 29-31 May 1996) endorsed
the revised European Business Plan, in which promoting good practice in the
use of DNA profiling as an investigative technique is one of the main priorities.
In order to implement this task, the INTERPOL European Committee decided at
its 15th Meeting on 5 November 1996 to set up the INTERPOL European Working
Party on DNA profiling.
The Final Report of the Interpol European Working Party on DNA profiling (new
name now: DNA MEG) has been discussed by the 67th General Assembly Session in
Cairo. Theworking group was advised to profit from the experience of other countries
in the field ofDNA use in criminal investigations in order to get a global harmonisation.
In this respect itwas agreed to invite representatives from all continents to
join the DNA MEG.
| 7.
What is the INTERPOL DNA profile Monitoring Expert Group (DNA MEG) about
and what are its tasks? |
|
|
The INTERPOL DNA MEG discusses the use of DNA profiling as an investigative
technique and will make recommendations concerning the use of DNA in criminal
investigations with a view to facilitating the worldwide use of this technique.
The objective of the group is to act as an international point of reference
facilitating the utilisation future development of DNA techniques. The recommendations
will address following areas:
- Investigation of crimes and incidents
- Establishing protocols for the application of DNA
- Data basing
- Facilitate training
Other tasks are
- Providing assistance and support to developing countries acting as a catalyst
for the expansion of DNA applications
- Widening co-operation with law enforcement agencies, international leading
societies and institutions dealing with or working on DNA profiling
- Getting a global overview about the trends in the sphere of DNA profiling
- Organization of DNA related conferences and working meetings
Following Interpol member states are represented in the DNA MEG:
Argentina, Australia, Austria, Belgium, France, Norway, South Africa, Spain,
United Kingdom and the USA.
The DNA MEG takes into consideration the work already done in this field by
other fora dealing with or working on DNA profiling. The current members representing
following international or national working groups before the DNA MEG:
AICEF-GITAD (Academica
Iberoamericana de Criminalistica y Estudios Forenses)
CODIS
(The FBI Laboratorys Combined DNA Index System)
EDNAP
(European DNA Profiling group),
ENFSI (European
Network on Forensic Science Institutes)
FBI (Federal Bureau
of Investigation)
FSS
(Forensic Science Service in UK)
GEP-ISFH
(Spanish and Portuguese working group - International Society for Forensic
Haemogenetics)
Interpol WG on DVI
(Working Group on Disaster Victim Identification)
ISFG (International
Society for Forensic Genetics)
NCIS (National
Criminal Intelligence Service in UK)
NDIS
(The FBIs National DNA Index System)
NIFS (National
Institute of Forensic Science - Australia)
PCWG (Police Co-operation
in the European Union)
SMANZFL
(Senior Managers Australian and New Zealand Forensic Laboratories)
SWGDAM
(Scientific Working Group on DNA Analysis Methods)
Updated April 2000